Hypomethylation and expression of pepsinogen a genes in the fundic mucosa of human stomach

Masao Ichinose, Kazumasa Miki, Masae Tatematsu, Chie Furihata, Masahiro Nobuhara, Yoshikazu Ichihara, Masao Tanji, Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama, Hiroshi Oka, Takayuki Takahashi, Takashi Kageyama, Kenji Takahashi

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    We have examined the correlation between the extents of methylation and expression of pepsinogen A genes in normal human tissues. Expression of pepsinogen A mRNA was detected only in the fundic mucosa of the stomach and both CCGG and GCGC sites in the tenes region were less methylated in the fundic mucosa than in other non-expressing tissues. Thus, there was an inverse correlation between the extents of methylation and expression of pepsinogen A genes and the role of DNA methylation in the regulation of pepsinogen A genes expression during normal differentiation was suggested.

    Original languageEnglish
    Pages (from-to)275-282
    Number of pages8
    JournalBiochemical and biophysical research communications
    Volume151
    Issue number1
    DOIs
    Publication statusPublished - 1988 Feb 29

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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