Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice

Kazunari Tanaka, Shoko Nishizono, Nozomi Makino, Shizuka Tamaru, Osamu Terai, Ikuo Ikeda

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


The hypoglycemic effects of Eriobotrya japonica seeds were investigated in type 2 diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats and KK-A y mice. The rats and mice were fed on a diet containing 10% powdered Eriobotrya japonica seeds with the coat intact for 4 months. Although the blood glucose concentration in the OLETF rats fed on the control diet without Eriobotrya japonica seeds was increased with time, the concentration in the OLETF rats fed on the diet with Eriobotrya japonica seeds was consistently low throughout the experimental period and was comparable to the level in Long-Evans Tokushima Otsuka (LETO) rats which are normal non-diabetic rats. Serum insulin was significantly lower in the OLETF rats fed on the Eriobotrya japonica seed diet than in those fed on the control diet at the termination of the experimental period. Eriobotrya japonica seeds suppressed the increment of blood glucose for 4 months and also effectively improved the glucose tolerance in the KK-Ay mice, these actions being mainly exerted by the ethanol extract of the seeds. These results suggest that Eriobotrya japonica seeds had a hypoglycemic property and the effect is attributable to the components extracted by ethanol.

Original languageEnglish
Pages (from-to)686-693
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Issue number3
Publication statusPublished - 2008
Externally publishedYes


  • Blood glucose
  • Eriobotrya japonica seed
  • Ethanol extract
  • Glucose tolerance
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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