TY - JOUR
T1 - Hypertrophic cranial pachymeningitis in MPO-ANCA-related vasculitis
T2 - a case report and literature review.
AU - Watanabe, Kimio
AU - Tani, Yoshihiro
AU - Kimura, Hiroshi
AU - Asai, Jun
AU - Tanaka, Kenichi
AU - Hayashi, Yoshimitsu
AU - Asahi, Koichi
AU - Nakayama, Masaaki
AU - Watanabe, Tsuyoshi
PY - 2013
Y1 - 2013
N2 - A 75-year-old woman presented with rapidly progressive glomerulonephritis with positive results for anti-myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA). Corticosteroid therapy was successfully introduced. However, 7 months later, magnetic resonance imaging revealed marked swelling in the falx cerebri and high density regions were apparent on gallium scintigraphy, leading to diagnosis of hypertrophic cranial pachymeningitis (HCP). Symptoms improved with intensified corticosteroid therapy, but radiological examination 9 months later revealed right nasal sinus inflammation accompanied by osteolytic change. Granulomatosis with polyangiitis (Wegener's) was finally diagnosed. HCP is an important complication in MPO-ANCA-related vasculitis, and needs to be considered during the clinical course.
AB - A 75-year-old woman presented with rapidly progressive glomerulonephritis with positive results for anti-myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA). Corticosteroid therapy was successfully introduced. However, 7 months later, magnetic resonance imaging revealed marked swelling in the falx cerebri and high density regions were apparent on gallium scintigraphy, leading to diagnosis of hypertrophic cranial pachymeningitis (HCP). Symptoms improved with intensified corticosteroid therapy, but radiological examination 9 months later revealed right nasal sinus inflammation accompanied by osteolytic change. Granulomatosis with polyangiitis (Wegener's) was finally diagnosed. HCP is an important complication in MPO-ANCA-related vasculitis, and needs to be considered during the clinical course.
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U2 - 10.5387/fms.59.56
DO - 10.5387/fms.59.56
M3 - Review article
C2 - 23842516
AN - SCOPUS:84890830887
VL - 59
SP - 56
EP - 62
JO - Fukushima Journal of Medical Sciences
JF - Fukushima Journal of Medical Sciences
SN - 0016-2590
IS - 1
ER -