Hypertrophic cranial pachymeningitis in MPO-ANCA-related vasculitis: a case report and literature review.

Kimio Watanabe, Yoshihiro Tani, Hiroshi Kimura, Jun Asai, Kenichi Tanaka, Yoshimitsu Hayashi, Koichi Asahi, Masaaki Nakayama, Tsuyoshi Watanabe

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

A 75-year-old woman presented with rapidly progressive glomerulonephritis with positive results for anti-myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA). Corticosteroid therapy was successfully introduced. However, 7 months later, magnetic resonance imaging revealed marked swelling in the falx cerebri and high density regions were apparent on gallium scintigraphy, leading to diagnosis of hypertrophic cranial pachymeningitis (HCP). Symptoms improved with intensified corticosteroid therapy, but radiological examination 9 months later revealed right nasal sinus inflammation accompanied by osteolytic change. Granulomatosis with polyangiitis (Wegener's) was finally diagnosed. HCP is an important complication in MPO-ANCA-related vasculitis, and needs to be considered during the clinical course.

Original languageEnglish
Pages (from-to)56-62
Number of pages7
JournalFukushima journal of medical science
Volume59
Issue number1
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Watanabe, K., Tani, Y., Kimura, H., Asai, J., Tanaka, K., Hayashi, Y., Asahi, K., Nakayama, M., & Watanabe, T. (2013). Hypertrophic cranial pachymeningitis in MPO-ANCA-related vasculitis: a case report and literature review. Fukushima journal of medical science, 59(1), 56-62. https://doi.org/10.5387/fms.59.56