Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine

A. Iguchi, K. Uemura, Y. Kunoh, H. Miura, T. Ishiguro, K. Nonogaki, T. Tamagawa, M. Gotoh, N. Sakamoto

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14 Citations (Scopus)

Abstract

We investigated the relationship between the hyperglycemia induced by the administration of neostigmine into the hippocampus and the hypothalamus. Prior to the injection of neostigmine (5×10-8 mol) into the hippocampus, 1 μl each of atropine or hexamethonium (5×10-11-5×10-8 mol) was injected into the bilateral ventromedial hypothalamus (VMH). Atropine suppressed in a dose-dependent manner the hyperglycemia induced by hippocampal administration of neostigmine, whereas hexamethonium had no significant effect. These observations suggest that the pathway for this experimental hyperglycemia involves, at least in part, the muscarinic cholinergic neurons in the VMH.

Original languageEnglish
Pages (from-to)1129-1131
Number of pages3
JournalNeuropharmacology
Volume30
Issue number10
DOIs
Publication statusPublished - 1991 Oct
Externally publishedYes

Keywords

  • blood glucose
  • cholinergic
  • hippocampus
  • hypothalamus

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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    Iguchi, A., Uemura, K., Kunoh, Y., Miura, H., Ishiguro, T., Nonogaki, K., Tamagawa, T., Gotoh, M., & Sakamoto, N. (1991). Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine. Neuropharmacology, 30(10), 1129-1131. https://doi.org/10.1016/0028-3908(91)90144-Z