Hyperferritinemia after adult allogeneic hematopoietic cell transplantation: Quantification of iron burden by determining non-transferrin-bound iron

Tatsunori Goto, Katsuya Ikuta, Yoshihiro Inamoto, Sonoko Kamoshita, Emi Yokohata, Daisuke Koyama, Koichi Onodera, Aika Seto, Keisuke Watanabe, Nobuhiko Imahashi, Shokichi Tsukamoto, Yukiyasu Ozawa, Katsunori Sasaki, Masafumi Ito, Yutaka Kohgo, Koichi Miyamura

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Iron overload is a common complication in allogeneic hematopoietic cell transplantation (HCT). We studied the prevalence of iron overload using serum ferritin from 122 allogeneic HCT survivors who had survived a median of 1259 (range 134-4261) days. We also quantified iron overload by determining non-transferrin-bound iron (NTBI), which reflects iron overload more directly than ferritin, and compared the results with those of the ferritin assay. Fifty-two patients (43 %) showed hyperferritinemia (HF) (serum ferritin >1000 ng/mL), and there was a moderate correlation between serum ferritin and the number of transfused red blood cell units (ρ = 0.71). In multivariate analyses, HF was a significant risk factor for liver dysfunction (P = 0.0001) and diabetes (P = 0.02), and was related to a lesser extent with performance status (P = 0.08). There was a significant correlation between serum ferritin and NTBI (ρ = 0.59); however, the association of NTBI with these outcomes was weaker than that of serum ferritin. In conclusion, serum ferritin is a good surrogate marker of iron overload after allogeneic HCT, and reflects organ damage more accurately than NTBI.

Original languageEnglish
Pages (from-to)125-134
Number of pages10
JournalInternational journal of hematology
Volume97
Issue number1
DOIs
Publication statusPublished - 2013 Jan
Externally publishedYes

Keywords

  • Ferritin
  • Hematopoietic cell transplantation
  • Hyperferritinemia
  • Iron overload
  • Non-transferrin-bound iron

ASJC Scopus subject areas

  • Hematology

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