Hypercoagulable state and disseminated intravascular coagulation following an effective chemotherapy in tumor-bearing rats

Haochuan Li, Yasuyuki Sasano, Katsuyoshi Hori, Kagayama Manabu, Qiuhang Zhang, Sachiko Saito, Maroh Suzuki

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2 Citations (Scopus)

Abstract

Objective. To detect the changes in blood coagulation system and clarify the related mechanisms of chemotherapy-induced disseminated intravascular coagulation. Methods. Changes in blood coagulation system and immunohistochemistry for fibrinogen were investigated in six groups of rats designed for different purposes. Results. Decreased platelet count, prolonged prothrombin time and active partial thromboplastin time, elevated fibrinogen level, and decreased antithrombin were observed in the rats receiving a newly developed chemotherapy (NDC group), in which mitomycin C was administered intravenously together with angiotensin. Accumulation of fibrinogen and microthrombi in the blood vessels of multiple organs were also found in the NDC group by immunohistochemistry and histopathological examination. Conclusions. Rapid reduction of tumor mass induced by an effective chemotherapy could cause hypercoagulable state and disseminated intravascular coagulation.

Original languageEnglish
Pages (from-to)951-955
Number of pages5
JournalChinese Medical Journal
Volume111
Issue number10
Publication statusPublished - 1998 Nov 14

ASJC Scopus subject areas

  • Medicine(all)

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