TY - JOUR
T1 - Hyperammonemia in a patient with short bowel syndrome and chronic renal failure
AU - Yokoyama, Keitaro
AU - Ogura, Yostike
AU - Kawabata, Masateru
AU - Hinoshita, Fumihiko
AU - Suzuki, Yoshio
AU - Hara, Sigeko
AU - Yamada, Akira
AU - Mimura, Nobuhide
AU - Nakayama, Masaaki
AU - Kawaguchi, Yoshindo
AU - Sakai, Osamu
PY - 1996
Y1 - 1996
N2 - A patient with short bowel syndrome (SBS) and renal failure developed a disturbance of consciousness associated with hyperammonemia. Abnormally low concentrations of ornithine, citrulline, and arginine were observed on the plasma aminogram. These results suggested that the activities of amino acid synthetase localized in the small intestinal flora were lost. The small intestine is required for arginine synthesis; thus, infusion limited to the essential amino acids to SBS patients will cause a deficiency of the urea cycle intermediates, ornithine, citrulline, and arginine and may lead to hyperammonemia. In addition, the renal insufficiency may have caused decreased excretion of ammonia. In this patient, supplemental arginine improved the symptoms.
AB - A patient with short bowel syndrome (SBS) and renal failure developed a disturbance of consciousness associated with hyperammonemia. Abnormally low concentrations of ornithine, citrulline, and arginine were observed on the plasma aminogram. These results suggested that the activities of amino acid synthetase localized in the small intestinal flora were lost. The small intestine is required for arginine synthesis; thus, infusion limited to the essential amino acids to SBS patients will cause a deficiency of the urea cycle intermediates, ornithine, citrulline, and arginine and may lead to hyperammonemia. In addition, the renal insufficiency may have caused decreased excretion of ammonia. In this patient, supplemental arginine improved the symptoms.
KW - Arginine
KW - Disturbed consciousness
KW - Hyperammonemia
KW - Renal insufficiency
KW - Short bowel syndrome
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U2 - 10.1159/000188964
DO - 10.1159/000188964
M3 - Article
C2 - 8730446
AN - SCOPUS:9044249320
VL - 72
SP - 693
EP - 695
JO - Nephron
JF - Nephron
SN - 0028-2766
IS - 4
ER -