Hyperammonemia in a patient with short bowel syndrome and chronic renal failure

Keitaro Yokoyama, Yostike Ogura, Masateru Kawabata, Fumihiko Hinoshita, Yoshio Suzuki, Sigeko Hara, Akira Yamada, Nobuhide Mimura, Masaaki Nakayama, Yoshindo Kawaguchi, Osamu Sakai

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19 Citations (Scopus)

Abstract

A patient with short bowel syndrome (SBS) and renal failure developed a disturbance of consciousness associated with hyperammonemia. Abnormally low concentrations of ornithine, citrulline, and arginine were observed on the plasma aminogram. These results suggested that the activities of amino acid synthetase localized in the small intestinal flora were lost. The small intestine is required for arginine synthesis; thus, infusion limited to the essential amino acids to SBS patients will cause a deficiency of the urea cycle intermediates, ornithine, citrulline, and arginine and may lead to hyperammonemia. In addition, the renal insufficiency may have caused decreased excretion of ammonia. In this patient, supplemental arginine improved the symptoms.

Original languageEnglish
Pages (from-to)693-695
Number of pages3
JournalNephron
Volume72
Issue number4
DOIs
Publication statusPublished - 1996 Jan 1

Keywords

  • Arginine
  • Disturbed consciousness
  • Hyperammonemia
  • Renal insufficiency
  • Short bowel syndrome

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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    Yokoyama, K., Ogura, Y., Kawabata, M., Hinoshita, F., Suzuki, Y., Hara, S., Yamada, A., Mimura, N., Nakayama, M., Kawaguchi, Y., & Sakai, O. (1996). Hyperammonemia in a patient with short bowel syndrome and chronic renal failure. Nephron, 72(4), 693-695. https://doi.org/10.1159/000188964