Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins in the blood of Alzheimer's disease patients and their potential as biomarkers

Yasukazu Yoshida, Atsushi Yoshikawa, Tomoya Kinumi, Yoko Ogawa, Yoshiro Saito, Kazuyuki Ohara, Hirokazu Yamamoto, Yasuharu Imai, Etsuo Niki

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a neurological disorder that has a considerable impact on the health of the elderly. Although oxidative stress has been implicated in the early stage of this disease, its detailed pathogenesis and therapeutic targets remain unknown. The diagnosis, particularly at the early stage, is important. In the present study, the levels of potential biomarkers such as total hydroxyoctadecadienoic acid (tHODE) and oxidatively modified peroxiredoxin (oxPrx)-2 and oxPrx-6 in plasma and/or erythrocytes were determined by a GC-MS apparatus and by two-dimensional electrophoresis, respectively. It was found that these levels in AD patients were significantly higher than those in the healthy controls. Furthermore, the tHODE levels increased with increasing clinical dementia ratings. Interestingly, vascular dementia patients could be distinguished by the correlation between plasma and erythrocyte tHODE levels or by that of tHODE with oxPrx in erythrocytes. These data further support that oxidative stress is indeed involved in AD and that the correlative measures of tHODE and oxPrx are potential biomarkers for its diagnosis.

Original languageEnglish
Pages (from-to)174-185
Number of pages12
JournalNeurobiology of Aging
Volume30
Issue number2
DOIs
Publication statusPublished - 2009 Feb 1
Externally publishedYes

Keywords

  • Alzheimers disease
  • Biomarker
  • Oxidatively modified peroxiredoxin
  • Total hydroxyoctadecadienoic acid (tHODE)
  • Vascular dementia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins in the blood of Alzheimer's disease patients and their potential as biomarkers'. Together they form a unique fingerprint.

Cite this