TY - JOUR
T1 - Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour
AU - Ahadian, Samad
AU - Banan Sadeghian, Ramin
AU - Yaginuma, Shin
AU - Ramón-Azcón, Javier
AU - Nashimoto, Yuji
AU - Liang, Xiaobin
AU - Bae, Hojae
AU - Nakajima, Ken
AU - Shiku, Hitoshi
AU - Matsue, Tomokazu
AU - Nakayama, Koji S.
AU - Khademhosseini, Ali
N1 - Publisher Copyright:
© 2015 The Royal Society of Chemistry.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Hydrogels with tunable electrical and mechanical properties have a wide range of biological applications in tissue engineering, biosensing, and biorobotics. In this work, palladium-based metallic glass sub-micron wires (PdMGSMWs) were employed to enhance the conductivity and mechanical strength of gelatin methacryloyl (GelMA) gels. The values of electrical resistivity and stiffness of hybrid GelMA-PdMGSMW hydrogels were varied by the concentration of the sub-micron wires in the gels. Compared with pristine GelMA gels, hybrid GelMA-PdMGSMW gels were more efficient in regulating adhesion and spreading of C2C12 myoblasts. Formation, contractility, and metabolic activity of C2C12 myotubes in GelMA hydrogels also increased upon inclusion of the PdMGSMWs and applying electrical stimulation. The latter phenomenon is likely because of the electrical conductivity of hybrid GelMA gels.
AB - Hydrogels with tunable electrical and mechanical properties have a wide range of biological applications in tissue engineering, biosensing, and biorobotics. In this work, palladium-based metallic glass sub-micron wires (PdMGSMWs) were employed to enhance the conductivity and mechanical strength of gelatin methacryloyl (GelMA) gels. The values of electrical resistivity and stiffness of hybrid GelMA-PdMGSMW hydrogels were varied by the concentration of the sub-micron wires in the gels. Compared with pristine GelMA gels, hybrid GelMA-PdMGSMW gels were more efficient in regulating adhesion and spreading of C2C12 myoblasts. Formation, contractility, and metabolic activity of C2C12 myotubes in GelMA hydrogels also increased upon inclusion of the PdMGSMWs and applying electrical stimulation. The latter phenomenon is likely because of the electrical conductivity of hybrid GelMA gels.
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U2 - 10.1039/c5bm00215j
DO - 10.1039/c5bm00215j
M3 - Article
C2 - 26343776
AN - SCOPUS:84944251772
VL - 3
SP - 1449
EP - 1458
JO - Biomaterials Science
JF - Biomaterials Science
SN - 2047-4830
IS - 11
ER -