Hydrogel-like elastic membrane consisting of semi-interpenetrating polymer networks based on a phosphorylcholine polymer and a segmented polyurethane

Yasuhiko Iwasaki, Keiko Shimakata, Nobuyuki Morimoto, Kimio Kurita

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

To obtain a hydrogel-like elastic membrane, we prepared semi-interpenetrating polymer networks (IPNs) by the radical polymerization of methacrylates such as 2-methacryloyloxyethyl phosphorylcholine (MPC). 2-hydroxyethylmethacrylate, and triethyleneglycol dimethacrylate diffused into segmented polyurethane (SPU) membranes swollen with a monomer mixture. The values of Young's modulus for the hydrated semi-IPN membranes were less than that for an SPU membrane because of higher hydration. but they were much higher than that for a hydrated MPC polymer gel (non-SPU). According to a thermal analysis, the MPC polymer influenced the segment association of SPU. The diffusion coefficient of 8-anilino-l-naphthalenesulfonic acid sodium salt from the semi-IPN membrane could be controlled with different MPC unit concentrations in the membrane, and it was about 7 × 102 times higher than that of the SPU membrane. Fibroblast cell adhesion on the semi-IPN membrane was effectively reduced by the MPC units. We concluded that semi-IPNs composed of the MPC polymer and SPU may be novel polymer materials possessing attractive mechanical, diffusive-release, and nonbiofouling properties.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume41
Issue number1
DOIs
Publication statusPublished - 2002 Jan 1
Externally publishedYes

Keywords

  • Diffusive release
  • Hydrogels
  • Interpenetrating networks (IPN)
  • Nonbiofouling
  • Phosphorylcholine polymer
  • Reinforcement
  • Segmented polyurethanes

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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