Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis

Toshinori Morisaku, Junji Watanabe, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)

Abstract

Hydration of polymer chains plays a key role for determining the extent of protein adsorption on polymeric materials. Here we investigated the hydration of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) chains, which resist protein adsorption and following cell adhesion effectively. The hydration was compared with that of poly(methoxy oligo(ethylene glycol)-monomethacrylate (Me(EG)nMA)) chains, which also have hydrophilic units. The poly(MPC) and poly(Me(EG)nMA) hydrogels with equilibrium water contents (EWCs) in the range from 86 to 97 wt% were prepared. By differential scanning calorimetric measurements, water in both the hydrogels was classified into two states: freezable and nonfreezable water. The poly(MPC) hydrogels had larger nonfreezable water than the poly(Me(EG)nMA) hydrogels even when their EWCs were similar, which indicated the higher hydrating ability of poly(MPC) chains. We suggested that the difference in the amount of nonfreezable water around polymer chains may influence the degree of protein adsorption resistance after contact with body fluid for a long period.

Original languageEnglish
Pages (from-to)4652-4657
Number of pages6
JournalPolymer
Volume49
Issue number21
DOIs
Publication statusPublished - 2008 Oct 6
Externally publishedYes

Keywords

  • 2-Methacryloyloxyethyl phosphorylcholine polymer
  • Hydrogel
  • Nonfreezable water

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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