We have proposed a hybrid single-carrier (SC) and multi-carrier (MC) system for next-generation mobile communication systems, where both high data rate and wide coverage system are attained by appropriately selecting SC or MC signal. We have confirmed effectiveness of the proposed hybrid system under single-cell environment. In this paper, the uplink throughput performance under multi-cell environment in the presence of inter-cell interference was calculated using computer simulation. The simulation results show that the hybrid system attains more than 10 times higher throughput than orthogonal frequency division multiple access (OFDMA) at a cumulative probability of 10% and 1.2 times higher throughput than SC-frequency division multiple access (FDMA) at a cumulative probability of 90%. The above result show that the proposed hybrid systems is useful in multi-cell environment as well as single-cell environment.