Human REG family genes are tandemly ordered in a 95-kilobase region of chromosome 2p12

Hikari Miyashita, Kan ichi Nakagawara, Mitsuko Mori, Yoichi Narushima, Naoya Noguchi, Shigeki Moriizumi, Shin Takasawa, Hideto Yonekura, Takuji Takeuchi, Hiroshi Okamoto

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Reg, first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet β-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG Iα, REG Iβ, REG-related sequence (RS) and HIPIPAP, have so far been isolated. In this study, we analyzed YAC clones containing the four genes and performed two-color FISH to determine the map order of the genes. The human REG family genes are tandemly ordered in the 95-kbp DNA region of chromosome 2p12 as follows: 2cen-HIPIPAP-RS-REG Iα-REG Iβ-ptel.

Original languageEnglish
Pages (from-to)429-433
Number of pages5
JournalFEBS Letters
Volume377
Issue number3
DOIs
Publication statusPublished - 1995 Dec 27

Keywords

  • (Human)
  • Chromosomal mapping
  • Gene cluster
  • Islet regeneration
  • Reg family
  • Two-color FISH
  • YAC

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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