TY - JOUR
T1 - Human REG family genes are tandemly ordered in a 95-kilobase region of chromosome 2p12
AU - Miyashita, Hikari
AU - Nakagawara, Kan ichi
AU - Mori, Mitsuko
AU - Narushima, Yoichi
AU - Noguchi, Naoya
AU - Moriizumi, Shigeki
AU - Takasawa, Shin
AU - Yonekura, Hideto
AU - Takeuchi, Takuji
AU - Okamoto, Hiroshi
N1 - Funding Information:
Acknowledgments." We are indebted to Dr. K. Ishikawa for his help. Mr. Brent Bell assisted in preparing the manuscript for publication. This work has been supported in part by Grants-in-Aids for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan. H.M. is a recipient of a fellowship from the Japan Society for the Promotion of Science.
PY - 1995/12/27
Y1 - 1995/12/27
N2 - Reg, first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet β-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG Iα, REG Iβ, REG-related sequence (RS) and HIPIPAP, have so far been isolated. In this study, we analyzed YAC clones containing the four genes and performed two-color FISH to determine the map order of the genes. The human REG family genes are tandemly ordered in the 95-kbp DNA region of chromosome 2p12 as follows: 2cen-HIPIPAP-RS-REG Iα-REG Iβ-ptel.
AB - Reg, first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet β-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG Iα, REG Iβ, REG-related sequence (RS) and HIPIPAP, have so far been isolated. In this study, we analyzed YAC clones containing the four genes and performed two-color FISH to determine the map order of the genes. The human REG family genes are tandemly ordered in the 95-kbp DNA region of chromosome 2p12 as follows: 2cen-HIPIPAP-RS-REG Iα-REG Iβ-ptel.
KW - (Human)
KW - Chromosomal mapping
KW - Gene cluster
KW - Islet regeneration
KW - Reg family
KW - Two-color FISH
KW - YAC
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U2 - 10.1016/0014-5793(95)01381-4
DO - 10.1016/0014-5793(95)01381-4
M3 - Article
C2 - 8549770
AN - SCOPUS:0029584766
SN - 0014-5793
VL - 377
SP - 429
EP - 433
JO - FEBS Letters
JF - FEBS Letters
IS - 3
ER -