Human NAT10 is an ATP-dependent rna acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)

Tsutomu Suzuki, Satoshi Ito, Sayuri Horikawa, Tateki Suzuki, Hiroki Kawauchi, Yoshikazu Tanaka, Takeo Suzuki

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Human N-acetyltransferase 10 (NAT10) is known to be a lysine acetyltransferase that targets microtubules and histones and plays an important role in cell division. NAT10 is highly expressed in malignant tumors, and is also a promising target for therapies against laminopathies and premature aging. Here we report that NAT10 is an ATP-dependent RNA acetyltransferase responsible for formation of N4-acetylcytidine (ac4C) at position 1842 in the terminal helix of mammalian 18 S rRNA. RNAimediated knockdown of NAT10 resulted in growth retardation of human cells, and this was accompanied by high-level accumulation of the 30 S precursor of 18 S rRNA, suggesting that ac4C1842 formation catalyzed by NAT10 is involved in rRNA processing and ribosome biogenesis.

Original languageEnglish
Pages (from-to)35724-35730
Number of pages7
JournalJournal of Biological Chemistry
Volume289
Issue number52
DOIs
Publication statusPublished - 2014 Dec 26
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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