Human genome and diseases: Review - Immunology and functional genomics of Behçet's disease

M. Zierhut, N. Mizuki, S. Ohno, H. Inoko, A. Gül, K. Onoé, E. Isogai

    Research output: Contribution to journalReview articlepeer-review

    107 Citations (Scopus)

    Abstract

    Behçet's disease (BD) is a multisystemic inflammatory disorder. Although the cause and pathogenesis of BD are still unclear, there is evidence for genetic, immunologic and infectious factors at the onset or in the course of BD. This review focusses on the functional genomics and immunology of BD. HLA-B51 is the major disease susceptibility gene locus in BD. An increased number of γδ T cells in the peripheral blood and in the involved tissues have been reported. However, the T cells at the sites of inflammation appear to be a phenotypically distinct subset. There is also a significant γδ T cell proliferative response to mycobacterial 65-kDa heat shock protein peptides. Homologous peptides derived from the human 60-kDa heat shock protein were observed in BD patients. There is evidence that natural killer T cells may also play a role in BD.

    Original languageEnglish
    Pages (from-to)1903-1922
    Number of pages20
    JournalCellular and Molecular Life Sciences
    Volume60
    Issue number9
    DOIs
    Publication statusPublished - 2003 Sep 1

    Keywords

    • Behçet's disease
    • Coagulation and fibrinolytic pathway abnormalities
    • Cytokines
    • Endothelial dysfunction
    • Experimental autoimmune uveitis
    • HLA
    • Heat shock protein
    • Herpes simplex virus
    • NK-T-cells
    • Neutrophils
    • Streptococcus
    • T cells
    • Uveitis
    • Vasculitis

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology
    • Pharmacology
    • Cellular and Molecular Neuroscience
    • Cell Biology

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