Human Gene Therapy for Malignant Gliomas (Glioblastoma Multiforme and Anaplastic Astrocytoma) by In Vivo Transduction with Human Interferon β Gene Using Cationic Liposomes

Jun Yoshida, Masaaki Mizuno, Masazumi Fujii, Yasukazu Kajita, Norimoto Nakahara, Manabu Hatano, Ryuta Saito, Misato Nobayashi, Toshihiko Wakabayashi

Research output: Contribution to journalArticlepeer-review

111 Citations (Scopus)

Abstract

Transfer of interferon β gene via cationic liposomes has been found to induce regression of experimental glioma. We performed a pilot clinical trial of safety and effectiveness of this interferon β gene therapy in five patients with malignant glioma (glioblastoma multiforme or anaplastic astrocytoma). Transgene expression and antitumor activity were detected in four patients. Two patients showed a partial response (>50% tumor reduction) and two others had stable disease 10 weeks after beginning therapy. One patient could not be evaluated because of previous treatment with γ-knife therapy. This study suggests the feasibility and safety of interferon β gene therapy, which may become an important treatment option for patients with malignant glioma.

Original languageEnglish
Pages (from-to)77-86
Number of pages10
JournalHuman Gene Therapy
Volume15
Issue number1
DOIs
Publication statusPublished - 2004 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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