Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17

Naotoshi Kanda, Shin ichi Fukushige, Tomoaki Murotsu, Michihiro C. Yoshida, Masayuki Tsuchiya, Shigetaka Asano, Yoshito Kaziro, Shigekazu Nagata

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21-q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acutepromyelocytic leukemia.

Original languageEnglish
Pages (from-to)679-684
Number of pages6
JournalSomatic Cell and Molecular Genetics
Volume13
Issue number6
DOIs
Publication statusPublished - 1987 Nov 1
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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