TY - JOUR
T1 - Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17
AU - Kanda, Naotoshi
AU - Fukushige, Shin ichi
AU - Murotsu, Tomoaki
AU - Yoshida, Michihiro C.
AU - Tsuchiya, Masayuki
AU - Asano, Shigetaka
AU - Kaziro, Yoshito
AU - Nagata, Shigekazu
PY - 1987/11/1
Y1 - 1987/11/1
N2 - Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21-q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acutepromyelocytic leukemia.
AB - Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21-q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acutepromyelocytic leukemia.
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U2 - 10.1007/BF01534488
DO - 10.1007/BF01534488
M3 - Article
C2 - 3499671
AN - SCOPUS:0023447101
VL - 13
SP - 679
EP - 684
JO - Somatic Cell and Molecular Genetics
JF - Somatic Cell and Molecular Genetics
SN - 0740-7750
IS - 6
ER -