Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

Daniel Fisch, Barbara Clough, Marie Charlotte Domart, Vesela Encheva, Hironori Bando, Ambrosius P. Snijders, Lucy M. Collinson, Masahiro Yamamoto, Avinash R. Shenoy, Eva Maria Frickel

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)

    Abstract

    Fisch et al. find that GBP1 targets Toxoplasma vacuolar and parasite membranes for disruption of both membranes. In contrast, appearance of cytosolic Salmonella is GBP1 independent, but caspase-4 recruitment to bacteria and activation is GBP1 dependent. In a negative feedback loop, caspase-1 cleaves GBP1 and suppresses caspase-4-driven pyroptosis during Salmonella infection.

    Original languageEnglish
    Article number108008
    JournalCell Reports
    Volume32
    Issue number6
    DOIs
    Publication statusPublished - 2020 Aug 11

    Keywords

    • GBP1
    • Salmonella enterica Typhimurium
    • Toxoplasma gondii
    • apoptosis
    • caspases
    • inflammasomes
    • pyroptosis

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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