Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

Daniel Fisch, Barbara Clough, Marie Charlotte Domart, Vesela Encheva, Hironori Bando, Ambrosius P. Snijders, Lucy M. Collinson, Masahiro Yamamoto, Avinash R. Shenoy, Eva Maria Frickel

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Fisch et al. find that GBP1 targets Toxoplasma vacuolar and parasite membranes for disruption of both membranes. In contrast, appearance of cytosolic Salmonella is GBP1 independent, but caspase-4 recruitment to bacteria and activation is GBP1 dependent. In a negative feedback loop, caspase-1 cleaves GBP1 and suppresses caspase-4-driven pyroptosis during Salmonella infection.

Original languageEnglish
Article number108008
JournalCell Reports
Volume32
Issue number6
DOIs
Publication statusPublished - 2020 Aug 11

Keywords

  • GBP1
  • Salmonella enterica Typhimurium
  • Toxoplasma gondii
  • apoptosis
  • caspases
  • inflammasomes
  • pyroptosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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