Human Cytochrome P450IIE1 Gene: DraI Polymorphism and Susceptibility to Cancer

Fumiyuki Vematsu; Hideaki Kikuchi; Ikuko Sagami; Minro Watanabe; Fumiyuki Vematsu; Masakichi Motomiya; Tatsuya Abe; Chikashi Ishioka; Ryunosuke Kanamaru

doi:10.1620/tjem.168.113

Human Cytochrome P450IIE1 Gene: DraI Polymorphism and Susceptibility to Cancer

Fumiyuki Vematsu, Hideaki Kikuchi, Ikuko Sagami, Minro Watanabe, Fumiyuki Vematsu, Masakichi Motomiya, Tatsuya Abe, Chikashi Ishioka, Ryunosuke Kanamaru

Division of Cancer Science

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Human cytochrome P450IIE1(CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphism among lung cancer patients (n=74) differed from that among controls (n=73) with statistical significance of p<0.05. In addition, the distribution among patients with cancers of the digestive system (n=38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.

Original language	English
Pages (from-to)	113-117
Number of pages	5
Journal	Tohoku Journal of Experimental Medicine
Volume	168
Issue number	2
DOIs	https://doi.org/10.1620/tjem.168.113
Publication status	Published - 1992 Jan 1

Keywords

DraI polymorphism
cancers of the digestive system
human cytochrome P450IIE1 gene
lung cancer
susceptibility to cancer

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1620/tjem.168.113

Fingerprint Dive into the research topics of 'Human Cytochrome P450IIE1 Gene: DraI Polymorphism and Susceptibility to Cancer'. Together they form a unique fingerprint.

Cite this

Human Cytochrome P450IIE1 Gene : DraI Polymorphism and Susceptibility to Cancer. / Vematsu, Fumiyuki; Kikuchi, Hideaki; Sagami, Ikuko; Watanabe, Minro; Vematsu, Fumiyuki; Motomiya, Masakichi; Abe, Tatsuya; Ishioka, Chikashi; Kanamaru, Ryunosuke.

In: Tohoku Journal of Experimental Medicine, Vol. 168, No. 2, 01.01.1992, p. 113-117.

Research output: Contribution to journal › Article › peer-review

@article{4a5a3551583342b3b7c7d138a8005027,

title = "Human Cytochrome P450IIE1 Gene: DraI Polymorphism and Susceptibility to Cancer",

abstract = "Human cytochrome P450IIE1(CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphism among lung cancer patients (n=74) differed from that among controls (n=73) with statistical significance of p<0.05. In addition, the distribution among patients with cancers of the digestive system (n=38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.",

keywords = "DraI polymorphism, cancers of the digestive system, human cytochrome P450IIE1 gene, lung cancer, susceptibility to cancer",

author = "Fumiyuki Vematsu and Hideaki Kikuchi and Ikuko Sagami and Minro Watanabe and Fumiyuki Vematsu and Masakichi Motomiya and Tatsuya Abe and Chikashi Ishioka and Ryunosuke Kanamaru",

year = "1992",

month = jan,

day = "1",

doi = "10.1620/tjem.168.113",

language = "English",

volume = "168",

pages = "113--117",

journal = "Tohoku Journal of Experimental Medicine",

issn = "0040-8727",

publisher = "Tohoku University Medical Press",

number = "2",

}

TY - JOUR

T1 - Human Cytochrome P450IIE1 Gene

T2 - DraI Polymorphism and Susceptibility to Cancer

AU - Vematsu, Fumiyuki

AU - Kikuchi, Hideaki

AU - Sagami, Ikuko

AU - Watanabe, Minro

AU - Vematsu, Fumiyuki

AU - Motomiya, Masakichi

AU - Abe, Tatsuya

AU - Ishioka, Chikashi

AU - Kanamaru, Ryunosuke

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Human cytochrome P450IIE1(CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphism among lung cancer patients (n=74) differed from that among controls (n=73) with statistical significance of p<0.05. In addition, the distribution among patients with cancers of the digestive system (n=38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.

AB - Human cytochrome P450IIE1(CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphism among lung cancer patients (n=74) differed from that among controls (n=73) with statistical significance of p<0.05. In addition, the distribution among patients with cancers of the digestive system (n=38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.

KW - DraI polymorphism

KW - cancers of the digestive system

KW - human cytochrome P450IIE1 gene

KW - lung cancer

KW - susceptibility to cancer

UR - http://www.scopus.com/inward/record.url?scp=0026935175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026935175&partnerID=8YFLogxK

U2 - 10.1620/tjem.168.113

DO - 10.1620/tjem.168.113

M3 - Article

C2 - 1363974

AN - SCOPUS:0026935175

VL - 168

SP - 113

EP - 117

JO - Tohoku Journal of Experimental Medicine

JF - Tohoku Journal of Experimental Medicine

SN - 0040-8727

IS - 2

ER -