Human Cytochrome P450IIE1 Gene: DraI Polymorphism and Susceptibility to Cancer

Fumiyuki Vematsu; Hideaki Kikuchi; Ikuko Sagami; Minro Watanabe; Fumiyuki Vematsu; Masakichi Motomiya; Tatsuya Abe; Chikashi Ishioka; Ryunosuke Kanamaru

doi:10.1620/tjem.168.113

Human Cytochrome P450IIE1 Gene: DraI Polymorphism and Susceptibility to Cancer

Fumiyuki Vematsu, Hideaki Kikuchi, Ikuko Sagami, Minro Watanabe, Fumiyuki Vematsu, Masakichi Motomiya, Tatsuya Abe, Chikashi Ishioka, Ryunosuke Kanamaru

Division of Cancer Science

Research output: Contribution to journal › Article

31 Citations (Scopus)

Abstract

Human cytochrome P450IIE1(CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphism among lung cancer patients (n=74) differed from that among controls (n=73) with statistical significance of p<0.05. In addition, the distribution among patients with cancers of the digestive system (n=38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.

Original language	English
Pages (from-to)	113-117
Number of pages	5
Journal	Tohoku Journal of Experimental Medicine
Volume	168
Issue number	2
DOIs	https://doi.org/10.1620/tjem.168.113
Publication status	Published - 1992 Jan 1

Keywords

DraI polymorphism
cancers of the digestive system
human cytochrome P450IIE1 gene
lung cancer
susceptibility to cancer

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Vematsu, F., Kikuchi, H., Sagami, I., Watanabe, M., Vematsu, F., Motomiya, M., Abe, T., Ishioka, C., & Kanamaru, R. (1992). Human Cytochrome P450IIE1 Gene: DraI Polymorphism and Susceptibility to Cancer. Tohoku Journal of Experimental Medicine, 168(2), 113-117. https://doi.org/10.1620/tjem.168.113

Human Cytochrome P450IIE1 Gene : DraI Polymorphism and Susceptibility to Cancer. / Vematsu, Fumiyuki; Kikuchi, Hideaki; Sagami, Ikuko; Watanabe, Minro; Vematsu, Fumiyuki; Motomiya, Masakichi; Abe, Tatsuya; Ishioka, Chikashi; Kanamaru, Ryunosuke.

In: Tohoku Journal of Experimental Medicine, Vol. 168, No. 2, 01.01.1992, p. 113-117.

Research output: Contribution to journal › Article

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abstract = "Human cytochrome P450IIE1(CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphism among lung cancer patients (n=74) differed from that among controls (n=73) with statistical significance of p<0.05. In addition, the distribution among patients with cancers of the digestive system (n=38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.",

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