Human Cytochrome P450IIE1 Gene: DraI Polymorphism and Susceptibility to Cancer

Fumiyuki Vematsu, Hideaki Kikuchi, Ikuko Sagami, Minro Watanabe, Fumiyuki Vematsu, Masakichi Motomiya, Tatsuya Abe, Chikashi Ishioka, Ryunosuke Kanamaru

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Human cytochrome P450IIE1(CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphism among lung cancer patients (n=74) differed from that among controls (n=73) with statistical significance of p<0.05. In addition, the distribution among patients with cancers of the digestive system (n=38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalTohoku Journal of Experimental Medicine
Volume168
Issue number2
DOIs
Publication statusPublished - 1992 Jan 1

Keywords

  • DraI polymorphism
  • cancers of the digestive system
  • human cytochrome P450IIE1 gene
  • lung cancer
  • susceptibility to cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Vematsu, F., Kikuchi, H., Sagami, I., Watanabe, M., Vematsu, F., Motomiya, M., Abe, T., Ishioka, C., & Kanamaru, R. (1992). Human Cytochrome P450IIE1 Gene: DraI Polymorphism and Susceptibility to Cancer. Tohoku Journal of Experimental Medicine, 168(2), 113-117. https://doi.org/10.1620/tjem.168.113