TY - JOUR
T1 - Human Cytochrome P450IIE1 Gene
T2 - DraI Polymorphism and Susceptibility to Cancer
AU - Vematsu, Fumiyuki
AU - Kikuchi, Hideaki
AU - Sagami, Ikuko
AU - Watanabe, Minro
AU - Vematsu, Fumiyuki
AU - Motomiya, Masakichi
AU - Abe, Tatsuya
AU - Ishioka, Chikashi
AU - Kanamaru, Ryunosuke
PY - 1992
Y1 - 1992
N2 - Human cytochrome P450IIE1(CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphism among lung cancer patients (n=74) differed from that among controls (n=73) with statistical significance of p<0.05. In addition, the distribution among patients with cancers of the digestive system (n=38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.
AB - Human cytochrome P450IIE1(CYP2E) is involved in the metabolic activation of procarcinogens such as N-nitrosodimethylamine, benzene and ethyl carbamate. We screened DNA from 28 individuals for restriction fragment length polymorphisms (RFLPs) is the human P450IIE1 gene and detected an RFLP for the restriction endonuclease DraI. The distribution of the genotypes of this polymorphism among lung cancer patients (n=74) differed from that among controls (n=73) with statistical significance of p<0.05. In addition, the distribution among patients with cancers of the digestive system (n=38) was also different from that among controls. Our findings indicate an association between the DraI polymorphism of the IIE1 gene and susceptibility to cancers of the lung and the digestive system.
KW - DraI polymorphism
KW - cancers of the digestive system
KW - human cytochrome P450IIE1 gene
KW - lung cancer
KW - susceptibility to cancer
UR - http://www.scopus.com/inward/record.url?scp=0026935175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026935175&partnerID=8YFLogxK
U2 - 10.1620/tjem.168.113
DO - 10.1620/tjem.168.113
M3 - Article
C2 - 1363974
AN - SCOPUS:0026935175
VL - 168
SP - 113
EP - 117
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 2
ER -
