H2O2-dependent substrate oxidation by an engineered diiron site in a bacterial hemerythrin

Yasunori Okamoto, Akira Onoda, Hiroshi Sugimoto, Yu Takano, Shun Hirota, Donald M. Kurtz, Yoshitsugu Shiro, Takashi Hayashi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The O2-binding carboxylate-bridged diiron site in DcrH-Hr was engineered in an effort to perform the H2O2-dependent oxidation of external substrates. A His residue was introduced near the diiron site in place of a conserved residue, Ile119. The I119H variant promotes the oxidation of guaiacol and 1,4-cyclohexadiene upon addition of H2O2.

Original languageEnglish
Pages (from-to)3421-3423
Number of pages3
JournalChemical Communications
Volume50
Issue number26
DOIs
Publication statusPublished - 2014 Mar 4

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Okamoto, Y., Onoda, A., Sugimoto, H., Takano, Y., Hirota, S., Kurtz, D. M., Shiro, Y., & Hayashi, T. (2014). H2O2-dependent substrate oxidation by an engineered diiron site in a bacterial hemerythrin. Chemical Communications, 50(26), 3421-3423. https://doi.org/10.1039/c3cc48108e