How does toxoplama gondii invade host cells?

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Toxoplasma gondii is a highly prevalent protozoon that can infect all warm-blooded animals, including humans. It is frequently used as an Apicomplexan parasite model in research. In this review, the invasion mechanism of T. gondii is described as a representative Apicomplexan parasite. The invasion machinery of T. gondii consists of the moving junction and the glideosome, which is a specific motor system for Apicomplexan parasites. I provide details about the moving junction, parasite-secreted proteins and host adhesion receptors, the glideosome, and calcium signaling, which generates the power for the gliding mobility of T. gondii. A detailed understanding of parasite invasion can be useful for the development of new effective drugs to inhibit this event and disrupt the Apicomplexan life cycle.

Original languageEnglish
JournalJournal of Veterinary Medical Science
Volume80
Issue number11
DOIs
Publication statusPublished - 2018
Externally publishedYes

Keywords

  • Glideosome
  • Host adhesion receptor
  • Invasion
  • Moving junction
  • Toxoplasma gondii

ASJC Scopus subject areas

  • veterinary(all)

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