Abstract
The mesencephalic/rhombomere 1 border (isthmus) is an organizing center for early development of midbrain and cerebellum. In this review, we summarize recent progress in studies of Fgf signaling in the isthmus and discuss how the isthmus instructs the differentiation of the midbrain versus cerebellum. Fgf8 is shown to play a pivotal role in isthmic organizer activity. Only a strong Fgf signal mediated by Fgf8b activates the Ras-extracellular signal-regulated kinase (ERK) pathway, and this is sufficient to induce cerebellar development. A lower level of signaling transduced by Fgf8a, Fgf17 and Fgf18 induce midbrain development. Numerous feedback loops then maintain appropriate mesencephalon/rhombomerel and organizer gene expression.
| Original language | English |
|---|---|
| Pages (from-to) | 487-494 |
| Number of pages | 8 |
| Journal | Development Growth and Differentiation |
| Volume | 46 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2004 Dec 1 |
| Externally published | Yes |
Keywords
- Cerebellum
- Fgf8
- Isthmus
- Midbrain
- Organizer
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
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Cite this
Sato, T., Joyner, A. L., & Nakamura, H. (2004). How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development? Development Growth and Differentiation, 46(6), 487-494. https://doi.org/10.1111/j.1440-169x.2004.00769.x