How a nerve fiber repairs its cut end: Involvement of phospholipase A 2

Hiromu Yawo, Motoy Kuno

    Research output: Contribution to journalArticle

    100 Citations (Scopus)

    Abstract

    Following transection of a giant axon, the nerve membrane at the cut end is resealed within 5 to 30 minutes. This membrane resealing process is highly dependent upon temperature and extracellular calcium ions. The membrane resealing is triggered by excess calcium entering the axoplasm at the site of transection but is prevented by the application of phospholipase A2 inhibitors. We propose that calcium activated phospholipase A2 plays a central role in resealing of the ruptured nerve membrane.

    Original languageEnglish
    Pages (from-to)1351-1353
    Number of pages3
    JournalScience
    Volume222
    Issue number4630
    DOIs
    Publication statusPublished - 1983 Jan 1

    ASJC Scopus subject areas

    • General

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