Household transmission of influenza (H1N1-2009) in Japan: Age-specificity and reduction of household transmission risk by Zanamivir treatment

H. Nishiura, H. Oshitani

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

This study investigated household transmission data for influenza (H1N1-2009) in Japan in order to quantify the age-specific risk of infection and estimate the impact of antiviral treatment on the risk of household transmission. Among a total of 1547 households, involving 4609 household contacts, the secondary attack ratio (SAR) was estimated to be 11.4%. School children aged 5 - 18 years dominated the index cases. Age-specific infectiousness and susceptibility were highest among 0 - 4-year olds, with SAR estimated at 19.4% and 29.6%, respectively. Zanamivir treatment within 24 and 24 - 48 h of illness onset in index cases, respectively, reduced the risk of household transmission to 0.57 (95% CI 0.44, 0.73) and 0.58 (95% CI 0.38, 0.86) times that among those receiving the same treatment at > 48 h and those not receiving treatment. The preventive performance of antiviral treatment and prophylaxis should be further examined in randomized controlled trials.

Original languageEnglish
Pages (from-to)619-628
Number of pages10
JournalJournal of International Medical Research
Volume39
Issue number2
DOIs
Publication statusPublished - 2011

Keywords

  • Antiviral drugs
  • Epidemiology
  • H1N1-2009
  • Influenza
  • Neuraminidase inhibitors
  • Oseltamivir
  • Pandemic
  • Prophylaxis
  • Zanamivir

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Household transmission of influenza (H1N1-2009) in Japan: Age-specificity and reduction of household transmission risk by Zanamivir treatment'. Together they form a unique fingerprint.

Cite this