Honeycomb films of biodegradable polymers for tissue engineering

Takehiro Nishikawa, Keiko Arai, Junko Hayashi, Masahiko Hara, Masatsugu Shimomura

    Research output: Contribution to journalConference article

    14 Citations (Scopus)

    Abstract

    We report that microporous films (honeycomb films) can lead various types of cells to tissue formation. The honeycomb films were fabricated by applying a moist air to a spread polymer solution containing biodegradable polymers (poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL)) and an amphiphilic polymer. Hepatocytes were cultured on a self-supporting honeycomb film of PLLA. The hepatocytes formed a single layer of columnar shape cells with a thickness of 20 μm. The tissue formation of hepatocytes specifically occurred on the honeycomb film of PLLA, not on a flat film of PLLA. Three dimensional tissue structures were formed, when cells were cultured on both sides of the self-supporting honeycomb film. Double layers of hepatocytes were obtained by the method. Striated tissues such as heart and blood vessel could be reconstructed by utilizing a stretched honeycomb film of PCL.

    Original languageEnglish
    Pages (from-to)229-234
    Number of pages6
    JournalMaterials Research Society Symposium - Proceedings
    Volume724
    Publication statusPublished - 2002 Dec 1
    EventBiological and Biomimetic Materials - Properties to Function - San Francisco, CA, United States
    Duration: 2002 Apr 12002 Apr 5

    ASJC Scopus subject areas

    • Materials Science(all)
    • Condensed Matter Physics
    • Mechanics of Materials
    • Mechanical Engineering

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  • Cite this

    Nishikawa, T., Arai, K., Hayashi, J., Hara, M., & Shimomura, M. (2002). Honeycomb films of biodegradable polymers for tissue engineering. Materials Research Society Symposium - Proceedings, 724, 229-234.