Honeycomb films of biodegradable polymers for tissue engineering

Takehiro Nishikawa, Keiko Arai, Junko Hayashi, Masahiko Hara, Masatsugu Shimomura

    Research output: Contribution to journalConference articlepeer-review

    15 Citations (Scopus)


    We report that microporous films (honeycomb films) can lead various types of cells to tissue formation. The honeycomb films were fabricated by applying a moist air to a spread polymer solution containing biodegradable polymers (poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL)) and an amphiphilic polymer. Hepatocytes were cultured on a self-supporting honeycomb film of PLLA. The hepatocytes formed a single layer of columnar shape cells with a thickness of 20 μm. The tissue formation of hepatocytes specifically occurred on the honeycomb film of PLLA, not on a flat film of PLLA. Three dimensional tissue structures were formed, when cells were cultured on both sides of the self-supporting honeycomb film. Double layers of hepatocytes were obtained by the method. Striated tissues such as heart and blood vessel could be reconstructed by utilizing a stretched honeycomb film of PCL.

    Original languageEnglish
    Pages (from-to)229-234
    Number of pages6
    JournalMaterials Research Society Symposium - Proceedings
    Publication statusPublished - 2002
    EventBiological and Biomimetic Materials - Properties to Function - San Francisco, CA, United States
    Duration: 2002 Apr 12002 Apr 5

    ASJC Scopus subject areas

    • Materials Science(all)
    • Condensed Matter Physics
    • Mechanics of Materials
    • Mechanical Engineering


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