Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells

Hironori Fujiwara; Ako Kogure; Masahiro Sakamoto; Tohru Yamakuni; Yoshihiro Mimaki; Kiyoshi Murata; Nobuyuki Hitomi; Kikuji Yamaguchi; Yasushi Ohizumi

doi:10.1254/jphs.11001SC

Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells

Hironori Fujiwara, Ako Kogure, Masahiro Sakamoto, Tohru Yamakuni, Yoshihiro Mimaki, Kiyoshi Murata, Nobuyuki Hitomi, Kikuji Yamaguchi, Yasushi Ohizumi

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells. Moreover, CRE-mediated transcriptional activity by RJ was enhanced by nobiletin. U0126, a MEK inhibitor, inhibited CRE-mediated transcription by combining RJ plus nobiletin without affecting transcription by RJ alone. These results suggest that RJ stimulates CRE-mediated transcription via an ERK-independent cascade, whereas the increasing CRE-mediated transcriptional effect by nobiletin is dependent on ERK phosphorylation. Combining RJ plus nobiletin may activate effectively neuronal functions via enhancement of CRE-mediated transcription.

Original language	English
Pages (from-to)	384-387
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	116
Issue number	4
DOIs	https://doi.org/10.1254/jphs.11001SC
Publication status	Published - 2011

Keywords

Alzheimer's disease
CRE-mediated transcription
Honeybee royal jelly

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1254/jphs.11001SC

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Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells. / Fujiwara, Hironori; Kogure, Ako; Sakamoto, Masahiro; Yamakuni, Tohru; Mimaki, Yoshihiro; Murata, Kiyoshi; Hitomi, Nobuyuki; Yamaguchi, Kikuji; Ohizumi, Yasushi.

In: Journal of Pharmacological Sciences, Vol. 116, No. 4, 2011, p. 384-387.

Research output: Contribution to journal › Article › peer-review

Fujiwara, Hironori ; Kogure, Ako ; Sakamoto, Masahiro ; Yamakuni, Tohru ; Mimaki, Yoshihiro ; Murata, Kiyoshi ; Hitomi, Nobuyuki ; Yamaguchi, Kikuji ; Ohizumi, Yasushi. / Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells. In: Journal of Pharmacological Sciences. 2011 ; Vol. 116, No. 4. pp. 384-387.

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abstract = "To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells. Moreover, CRE-mediated transcriptional activity by RJ was enhanced by nobiletin. U0126, a MEK inhibitor, inhibited CRE-mediated transcription by combining RJ plus nobiletin without affecting transcription by RJ alone. These results suggest that RJ stimulates CRE-mediated transcription via an ERK-independent cascade, whereas the increasing CRE-mediated transcriptional effect by nobiletin is dependent on ERK phosphorylation. Combining RJ plus nobiletin may activate effectively neuronal functions via enhancement of CRE-mediated transcription.",

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author = "Hironori Fujiwara and Ako Kogure and Masahiro Sakamoto and Tohru Yamakuni and Yoshihiro Mimaki and Kiyoshi Murata and Nobuyuki Hitomi and Kikuji Yamaguchi and Yasushi Ohizumi",

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AU - Fujiwara, Hironori

AU - Kogure, Ako

AU - Sakamoto, Masahiro

AU - Yamakuni, Tohru

AU - Mimaki, Yoshihiro

AU - Murata, Kiyoshi

AU - Hitomi, Nobuyuki

AU - Yamaguchi, Kikuji

AU - Ohizumi, Yasushi

PY - 2011

Y1 - 2011

N2 - To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells. Moreover, CRE-mediated transcriptional activity by RJ was enhanced by nobiletin. U0126, a MEK inhibitor, inhibited CRE-mediated transcription by combining RJ plus nobiletin without affecting transcription by RJ alone. These results suggest that RJ stimulates CRE-mediated transcription via an ERK-independent cascade, whereas the increasing CRE-mediated transcriptional effect by nobiletin is dependent on ERK phosphorylation. Combining RJ plus nobiletin may activate effectively neuronal functions via enhancement of CRE-mediated transcription.

AB - To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells. Moreover, CRE-mediated transcriptional activity by RJ was enhanced by nobiletin. U0126, a MEK inhibitor, inhibited CRE-mediated transcription by combining RJ plus nobiletin without affecting transcription by RJ alone. These results suggest that RJ stimulates CRE-mediated transcription via an ERK-independent cascade, whereas the increasing CRE-mediated transcriptional effect by nobiletin is dependent on ERK phosphorylation. Combining RJ plus nobiletin may activate effectively neuronal functions via enhancement of CRE-mediated transcription.

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KW - CRE-mediated transcription

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Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells

Abstract

Keywords

ASJC Scopus subject areas

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