Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells

Hironori Fujiwara, Ako Kogure, Masahiro Sakamoto, Tohru Yamakuni, Yoshihiro Mimaki, Kiyoshi Murata, Nobuyuki Hitomi, Kikuji Yamaguchi, Yasushi Ohizumi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

To prove the pharmacological actions of honeybee royal jelly (RJ) on the nervous system, we examined the effects of RJ on CRE-mediated transcription. RJ increased CRE-mediated transcription in PC12D cells. Moreover, CRE-mediated transcriptional activity by RJ was enhanced by nobiletin. U0126, a MEK inhibitor, inhibited CRE-mediated transcription by combining RJ plus nobiletin without affecting transcription by RJ alone. These results suggest that RJ stimulates CRE-mediated transcription via an ERK-independent cascade, whereas the increasing CRE-mediated transcriptional effect by nobiletin is dependent on ERK phosphorylation. Combining RJ plus nobiletin may activate effectively neuronal functions via enhancement of CRE-mediated transcription.

Original languageEnglish
Pages (from-to)384-387
Number of pages4
JournalJournal of Pharmacological Sciences
Volume116
Issue number4
DOIs
Publication statusPublished - 2011

Keywords

  • Alzheimer's disease
  • CRE-mediated transcription
  • Honeybee royal jelly

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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