Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma

Y. Sonoda, T. Yoshimoto, T. Sekiya

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    76 Citations (Scopus)

    Abstract

    Loci on chromosome 9p are frequently deleted in several malignant tumors, suggesting the presence of putative tumor suppressor genes. The MTS1/p16 and MTS2/p15 genes on 9p are considered to be candidates. Binding of p15 and p16 cell cycle-regulatory proteins to the cyclin dependent protein kinase CDK4 inhibits CDK4/cyclin D dependent phosphorylation of retinoblastoma protein. We analysed the DNAs from 37 gliomas of several grades of malignancy for allelic loss of chromosome 9p and abberations of the MTS1/p16 and MTS2/p15 genes. We detected losses of one allele and homozygous deletions at loci, including those of the MTS1/p16 and MTS2/p15 genes, in 10 and 3 tumors, respectively. However, we did not detect any tumor-specific mutation in the two genes. The CDK4 gene was amplified in two malignant gliomas without homozygous deletion of the MTS1/p16 and MTS2/p15 genes and one malignant glioma with an allelic loss of the genes. These data suggest that aberrations of the genes coding for components of the cell cycle-regulatory system occured in at least 15 of 37 gliomas.

    Original languageEnglish
    Pages (from-to)2145-2149
    Number of pages5
    JournalOncogene
    Volume11
    Issue number10
    Publication statusPublished - 1995

    Keywords

    • CDK4 gene
    • Glioma
    • Homozygous deletion
    • MTS1/p16 gene
    • MTS2/p15 gene

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics
    • Cancer Research

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