HOMA-IR values are associated with glycemic control in Japanese subjects without diabetes or obesity: The KOBE study

Takumi Hirata, Aya Higashiyama, Yoshimi Kubota, Kunihiro Nishimura, Daisuke Sugiyama, Aya Kadota, Yoko Nishida, Hironori Imano, Tomofumi Nishikawa, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura

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12 Citations (Scopus)

Abstract

Background: Several studies have reported that insulin resistance was a major risk factor for the onset of type 2 diabetes mellitus in individuals without diabetes or obesity. We aimed to clarify the association between insulin resistance and glycemic control in Japanese subjects without diabetes or obesity. Methods: We conducted a community-based cross-sectional study including 1083 healthy subjects (323 men and 760 women) in an urban area. We performed multivariate regression analyses to estimate the association between the homeostasis model assessment of insulin resistance (HOMA-IR) values and markers of glycemic control, including glycated haemoglobin (HbA1c), 1,5-anhydroglucitol (1,5-AG), and fasting plasma glucose (FPG) levels, after adjustment for potential confounders. Results: Compared with the lowest tertile of HOMA-IR values, the highest tertile was significantly associated with HbA1c and FPG levels after adjustment for potential confounders, both in men (HbA1c: β = 1.83, P = 0.001; FPG: β = 0.49, P < 0.001) and women (HbA1c: β = 0.82, P = 0.008; FPG: β = 0.39, P < 0.001). The highest tertile of HOMA-IR values was inversely associated with 1,5-AG levels compared with the lowest tertile (β = -18.42, P = 0.009) only in men. Conclusions: HOMA-IR values were associated with markers of glycemic control in Japanese subjects without diabetes or obesity. Insulin resistance may influence glycemic control even in a lean, non-diabetic Asian population.

Original languageEnglish
Pages (from-to)407-414
Number of pages8
Journaljournal of epidemiology
Volume25
Issue number6
DOIs
Publication statusPublished - 2015

Keywords

  • Epidemiology
  • Glycemic control
  • Homeostasis model assessment of insulin resistance

ASJC Scopus subject areas

  • Epidemiology

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    Hirata, T., Higashiyama, A., Kubota, Y., Nishimura, K., Sugiyama, D., Kadota, A., Nishida, Y., Imano, H., Nishikawa, T., Miyamatsu, N., Miyamoto, Y., & Okamura, T. (2015). HOMA-IR values are associated with glycemic control in Japanese subjects without diabetes or obesity: The KOBE study. journal of epidemiology, 25(6), 407-414. https://doi.org/10.2188/jea.JE20140172