Hollow optical-fiber based infrared spectroscopy for measurement of blood glucose level by using multi-reflection prism

Saiko Kino, Suguru Omori, Takashi Katagiri, Yuji Matsuura

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

A mid-infrared attenuated total reflection (ATR) spectroscopy system employing hollow optical fibers and a trapezoidal multi-reflection ATR prism has been developed to measure blood glucose levels. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. An analysis of in vivo measurements of human inner lip mucosa revealed clear signatures of glucose in the difference spectra between ones taken during the fasting state and ones taken after ingestion of glucose solutions. A calibration plot based on the absorption peak at 1155 cm-1 that originates from the pyranose ring structure of glucose gave measurement errors less than 20%.

Original languageEnglish
Article number254610
Pages (from-to)701-708
Number of pages8
JournalBiomedical Optics Express
Volume7
Issue number2
DOIs
Publication statusPublished - 2016 Jan 29

Keywords

  • Fiber optics
  • Fourier transforms
  • Infrared
  • Medical optics instrumentation
  • Spectroscopy

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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