Hodgkin's disease associated with chronic myeloid leukemia: Determination of bcr-abl rearrangement in paraffin-embedded tumors using the polymerase chain reaction

Y. Takimoto, O. Tanabe, A. Kuramoto, N. Sasaki, K. Nanba

Research output: Contribution to journalArticle

Abstract

A patient showing lymph node enlargement and tumors in the neck and axilla in the course of Philadelphia (Ph1) chromosome-positive chronic myeloid leukemia (CML) was seen. There were no hematological findings suggestive of crisis. RNA was isolated from formalin-fixed and paraffin-embedded tissue specimens for the polymerase chain reaction of bcr-abl. CML-type products were detected in the peripheral blood, but no bcr-abl products were found in the lymph nodes. These findings indicate a very rare case in which Hodgkin's disease developed during the course of CML.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalActa Haematologica
Volume92
Issue number2
DOIs
Publication statusPublished - 1994

Keywords

  • Chronic myeloid leukemia CML
  • Hodgkin's disease
  • Ph chromosome
  • Polymerase chain reaction PCR
  • bcr-abl

ASJC Scopus subject areas

  • Hematology

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