Hodgkin-like anaplastic large cell lymphoma (previously designated in the REAL classification) has same immunophenotypic features to classical Hodgkin lymphoma

Jun Ichi Tamaru, Michihide Tokuhira, Nozomi Nittsu, Shigeo Nakamura, Ryo Ichinohasama, Ritsuro Suzuki, Hiraki Mori, Toshiyuki Takagi, Takahiro Suzuki, Jun Itami, Shinji Itoyama, Atsuo Mikata

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

In the WHO classification, the majority of Hodgkin-like ALCL cases as defined by the REAL classification are considered to be CHL. However, establishing a histological diagnosis for the gray zone between CHL and ALCL is often confusing. In this study, we re-evaluated such cases by performing immunohistochemistry with antibodies against PAX-5/BSAP, Oct.2, and BOB.1/OBF.1. Expression of PAX-5/BSAP was observed in 88% (76/87) of CHL specimens and none (0/11) of ALK-positive ALCL specimens. Among specimens of Hodgkin-like ALCL and ALK-negative ALCL, expression of PAX-5/BSAP was observed in 77% (20/26) and 18% (3/17), respectively. Most of the PAX-5/BSAP-positive specimens were negative for Oct.2 and/or BOB.1/OBF.1 except for four CHL specimens. Our results may support the WHO classification in which most cases of Hodgkin-like ALCL are classified as CHL. However, the patients with Hodgkin-like ALCL with CHL-immunophenotype (PAX-5/BSAP-positive and negative for Oct.2 and/or BOB.1) did not have a favorable outcome, with a 5-year OS rate of 58%.

Original languageEnglish
Pages (from-to)1127-1138
Number of pages12
JournalLeukemia and Lymphoma
Volume48
Issue number6
DOIs
Publication statusPublished - 2007 Jun

Keywords

  • Anaplastic large cell lymphoma
  • Anaplastic variant
  • BOB.1
  • Cytotoxic molecule
  • Diffuse large B-cell lymphoma
  • Hodgkin lymphoma
  • Hodgkin-like ALCL
  • Immunohistochemistry
  • Oct.2
  • PAX-5/BSAP

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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