Hoarseness due to bilateral vocal cord paralysis as an initial manifestation of familial amyotrophic lateral sclerosis

Jiro Fukae, Shin Ichiro Kubo, Nobutaka Hattori, Kaoru Komatsu, Masaaki Kato, Masashi Aoki, Yoshikuni Mizuno

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Bulbar palsy is unusual as an initial manifestation of amyotrophic lateral sclerosis (ALS), although common in the advanced stages. In terms of bulbar palsy as a presenting symptom, dysarthria and dysphagia are of common features. Hoarseness, however, is an initial symptom of ALS in only a small number of patients. We report a 43-year-old female with hoarseness due to bilateral vocal cord paralysis as the first manifestation of ALS. Gene analysis revealed a heterozygous missense mutation in the SOD1 gene, which resulted in an amino acid substitution of isoleucine 149 by threonine. Hoarseness can be the initial symptom of ALS. Therefore, in cases of bilateral vocal cord paralysis of unknown etiology, ALS should be taken into consideration.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalAmyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Volume6
Issue number2
DOIs
Publication statusPublished - 2005 Jun

Keywords

  • Bilateral vocal cord paralysis
  • Familial amyotrophic lateral sclerosis (FALS)
  • Hoarseness
  • SOD1

ASJC Scopus subject areas

  • Clinical Neurology

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