Hoarseness due to bilateral vocal cord paralysis as an initial manifestation of familial amyotrophic lateral sclerosis

Jiro Fukae; Shin Ichiro Kubo; Nobutaka Hattori; Kaoru Komatsu; Masaaki Kato; Masashi Aoki; Yoshikuni Mizuno

doi:10.1080/14660820510034451

Hoarseness due to bilateral vocal cord paralysis as an initial manifestation of familial amyotrophic lateral sclerosis

Jiro Fukae, Shin Ichiro Kubo, Nobutaka Hattori, Kaoru Komatsu, Masaaki Kato, Masashi Aoki, Yoshikuni Mizuno

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Bulbar palsy is unusual as an initial manifestation of amyotrophic lateral sclerosis (ALS), although common in the advanced stages. In terms of bulbar palsy as a presenting symptom, dysarthria and dysphagia are of common features. Hoarseness, however, is an initial symptom of ALS in only a small number of patients. We report a 43-year-old female with hoarseness due to bilateral vocal cord paralysis as the first manifestation of ALS. Gene analysis revealed a heterozygous missense mutation in the SOD1 gene, which resulted in an amino acid substitution of isoleucine 149 by threonine. Hoarseness can be the initial symptom of ALS. Therefore, in cases of bilateral vocal cord paralysis of unknown etiology, ALS should be taken into consideration.

Original language	English
Pages (from-to)	122-124
Number of pages	3
Journal	Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Volume	6
Issue number	2
DOIs	https://doi.org/10.1080/14660820510034451
Publication status	Published - 2005 Jun

Keywords

Bilateral vocal cord paralysis
Familial amyotrophic lateral sclerosis (FALS)
Hoarseness
SOD1

ASJC Scopus subject areas

Clinical Neurology

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10.1080/14660820510034451

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Hoarseness due to bilateral vocal cord paralysis as an initial manifestation of familial amyotrophic lateral sclerosis. / Fukae, Jiro; Kubo, Shin Ichiro; Hattori, Nobutaka; Komatsu, Kaoru; Kato, Masaaki; Aoki, Masashi; Mizuno, Yoshikuni.

In: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, Vol. 6, No. 2, 06.2005, p. 122-124.

Research output: Contribution to journal › Article › peer-review

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