hnRNP B1 protein may be a possible prognostic factor in squamous cell carcinoma of the lung

Shulin Wu, Masami Sato, Chiaki Endo, Akira Sakurada, Boming Dong, Hirokazu Aikawa, Yan Chen, Yoshinori Okada, Yuhji Matsumura, Eisaburo Sueoka, Takashi Kondo

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Heterogeneous nuclear ribonucleoprotein (hnRNP) B1 is an RNA-binding protein that is required for the maturation of mRNA precursor. It was previously reported that hnRNP A2/B1 was overexpressed at the early clinical stage of lung cancer, and that hnRNP B1 protein, a splicing variant of hnRNP A2 mRNA, was elevated in lung cancer tissues. In this study, we applied the immunohistochemical method, using anti-hnRNP B1 antibody to analyze the usefulness of the hnRNP B1 antibody as a prognostic marker and also as a marker useful for early detection. A total of 206 specimens were examined. Histological examination revealed this protein to be positive in 79 (71.2%) of 111 squamous cell carcinomas and in 45 (64.3%) of 70 adenocarcinomas, respectively. This protein was also expressed in 24 (63.2%) of 38 roentgenographically occult carcinomas and in seven (63.6%) of 11 dysplastic lesions. These findings suggest the possible participation of this protein in early carcinogenesis. Furthermore, the survival curve of the squamous cell carcinoma patients with hnRNP B1 overexpresseion showed a better prognosis compared with that of the patients without hnRNP B1 expression (P=0.014), whereas in adenocarcinoma patients, there was no such a difference between them (P=0.889). These findings indicate that hnRNP B1 could be a useful marker for the early detection of bronchogenic squamous cell carcinoma and that it may be a prognostic factor in this cell type.

Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalLung Cancer
Issue number2
Publication statusPublished - 2003 Aug 1


  • Biomarker
  • Borderline lesion
  • Lung cancer-early stage
  • Prognostic factor
  • hnRNP B1 antibody

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research


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