HMG-CoA reductase inhibitors pravastatin, lovastatin and simvastatin suppress delayed rectifier K+-channel currents in murine thymocytes

Itsuro Kazama, Asuka Baba, Yoshio Maruyama

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background Since lymphocytes predominantly express delayed rectifier K +-channels (Kv1.3) that trigger lymphocyte activation, statins, which exert immunosuppressive effects, would affect the channel currents. Methods Employing the patch-clamp technique in murine thymocytes, we examined the effects of statins on Kv1.3-channel currents and the membrane capacitance (Cm). Results Pravastatin significantly suppressed the pulse-end currents of the channels. Lovastatin and simvastatin also suppressed the peak currents, significantly decreasing the Cm. Conclusions This study demonstrated for the first time that statins inhibit thymocyte Kv1.3-channels. The slow inactivation patterns induced by lovastatin and simvastatin may be associated with their accumulation in the plasma membranes.

Original languageEnglish
Pages (from-to)712-717
Number of pages6
JournalPharmacological Reports
Volume66
Issue number4
DOIs
Publication statusPublished - 2014 Aug

Keywords

  • HMG-CoA reductase inhibitors (statins)
  • Immunosuppressive effects
  • Kv1.3-channel
  • Lymphocytes

ASJC Scopus subject areas

  • Pharmacology

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