Histopathological studies of a new liquid embolization method using estrogen-alcohol and polyvinyl acetate. Experimental evaluations with a model of cortical arterial cannulation in the canine brain

Ching Chan Su, Akira Takahashi, Takashi Yoshimoto, Takayuki Sugawara

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

This experimental report evaluates the histopathological effects of a new embolization method using estrogen-alcohol (E-A) and polyvinyl acetate solution (PVac) as tested on 21 mongrel dogs. Three other animals treated with normal saline served as controls. All agents were introduced through an isolated cortical artery. Estrogen-alcohol induced immediate occlusion of small vessels (<20 μmm), and then progressive obstruction of larger ones (200-300 μm) within several days. Animals treated with PVac showed vascular obliteration (> 100 μmm) and moderate chronic fibrosis. The effects of embolization using E-A followed by PVac were found to have the combined advantages of both materials, showing diffuse occlusion of the vascular network with less tissue reaction. Hyalinization of embolized vessels with extensive fibrosis occurred afterward. For 6 weeks there was no evidence of recanalization or foreign body giant cell reaction. This study shows that E-A and PVac are capable of producing vascular occlusions with only mild tissue reaction. Because they are easily controllable and have no adverse effects, they may be suitable for intravascular application in the central nervous system.

Original languageEnglish
Pages (from-to)4-11
Number of pages8
JournalSurgical Neurology
Volume36
Issue number1
DOIs
Publication statusPublished - 1991 Jul

Keywords

  • Embolization agent
  • Estrogen-alcohol
  • Experiment
  • Histopathological studies
  • Polyvinyl acetate

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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