Histopathological Changes in Spontaneously Hypertensive Rats after Feeding of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) Mushroom Diets

Yearul Kabir, Michio Komai, Shuichi Kimura, Tadahiko Hoshino

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Histopathological changes in spontaneously hypertensive rats were studied after the animals had been fed Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) mushroom powder diets, with 0.5% NaCl solution as drinking water for 9 weeks. Histological changes in control and Shiitake-fed rats were essentially the same, consisting of necrosis of the medial smooth muscle cells, vacuolization in the media of the aorta, fatty liver development, maceration in the myocardial muscle cells and vacuolization in the myocardium. In Maitake-fed animals large amounts of glycogen were observed in the liver, but the animals were otherwise normal in all respects. Dietary Maitake seems to play an important role in preventing the histological degenerative changes in SHR and thus may imply some benefits to be gained through blood pressure reduction and an improvement of lipid metabolism.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalJournal of Clinical Biochemistry and Nutrition
Volume6
Issue number3
DOIs
Publication statusPublished - 1989

Keywords

  • blood pressure
  • histopathology
  • mushrooms
  • spontaneously hypertensive rat (SHR)

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Histopathological Changes in Spontaneously Hypertensive Rats after Feeding of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) Mushroom Diets'. Together they form a unique fingerprint.

Cite this