Histological complete response in a case of advanced gastric cancer treated by neo-adjuvant chemotherapy with S-1/CDDP

Noriko Oshima, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masanori Tokunaga, Norihiko Sugisawa, Yusuke Taki, Yoko Motegi, Narikazu Boku, Keiko Sasaki, Masanori Terashima

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A 59-year-old male was found to have advanced gastric cancer with multiple lymph node metastasis including para-aortic lymph nodes (cT3, cN3, cM0, cH0, cP0, cStage IV). Since curative surgery was deemed not feasible, we tried neoadjuvant chemotherapy expecting downstaging of the tumor. S-1 (120 mg/body) was orally administered for three weeks followed by one week rest, and CDDP (60 mg/m2) was administered on day 8. Three courses of treatment resulted in a marked shrink-age of the primary lesion and a reduction of lymph nodes. He was judged as clinical PR by RECIST, and a radical resection was considered possible. Laparotomy revealed neither ascites nor peritoneal dissemination, and he underwent total gastrectomy, splenectomy and D2+para-aortic lymph node dissection with curative intent. The histological diagnosis revealed complete disappearance of cancer cells in the primary lesion of the stomach and lymph nodes, confirming a pathological complete response. The patient has been alive for six months without recurrence.

Original languageEnglish
Pages (from-to)697-701
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume37
Issue number4
Publication statusPublished - 2010 Apr 6
Externally publishedYes

Keywords

  • Gastric cancer
  • Neo-adjuvant chemotherapy
  • Para-aortic lymph node
  • Pathological CR

ASJC Scopus subject areas

  • Medicine(all)

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