TY - JOUR
T1 - Histological complete response in a case of advanced gastric cancer treated by neo-adjuvant chemotherapy with S-1/CDDP
AU - Oshima, Noriko
AU - Tanizawa, Yutaka
AU - Bando, Etsuro
AU - Kawamura, Taiichi
AU - Tokunaga, Masanori
AU - Sugisawa, Norihiko
AU - Taki, Yusuke
AU - Motegi, Yoko
AU - Boku, Narikazu
AU - Sasaki, Keiko
AU - Terashima, Masanori
PY - 2010/4/6
Y1 - 2010/4/6
N2 - A 59-year-old male was found to have advanced gastric cancer with multiple lymph node metastasis including para-aortic lymph nodes (cT3, cN3, cM0, cH0, cP0, cStage IV). Since curative surgery was deemed not feasible, we tried neoadjuvant chemotherapy expecting downstaging of the tumor. S-1 (120 mg/body) was orally administered for three weeks followed by one week rest, and CDDP (60 mg/m2) was administered on day 8. Three courses of treatment resulted in a marked shrink-age of the primary lesion and a reduction of lymph nodes. He was judged as clinical PR by RECIST, and a radical resection was considered possible. Laparotomy revealed neither ascites nor peritoneal dissemination, and he underwent total gastrectomy, splenectomy and D2+para-aortic lymph node dissection with curative intent. The histological diagnosis revealed complete disappearance of cancer cells in the primary lesion of the stomach and lymph nodes, confirming a pathological complete response. The patient has been alive for six months without recurrence.
AB - A 59-year-old male was found to have advanced gastric cancer with multiple lymph node metastasis including para-aortic lymph nodes (cT3, cN3, cM0, cH0, cP0, cStage IV). Since curative surgery was deemed not feasible, we tried neoadjuvant chemotherapy expecting downstaging of the tumor. S-1 (120 mg/body) was orally administered for three weeks followed by one week rest, and CDDP (60 mg/m2) was administered on day 8. Three courses of treatment resulted in a marked shrink-age of the primary lesion and a reduction of lymph nodes. He was judged as clinical PR by RECIST, and a radical resection was considered possible. Laparotomy revealed neither ascites nor peritoneal dissemination, and he underwent total gastrectomy, splenectomy and D2+para-aortic lymph node dissection with curative intent. The histological diagnosis revealed complete disappearance of cancer cells in the primary lesion of the stomach and lymph nodes, confirming a pathological complete response. The patient has been alive for six months without recurrence.
KW - Gastric cancer
KW - Neo-adjuvant chemotherapy
KW - Para-aortic lymph node
KW - Pathological CR
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M3 - Article
C2 - 20414029
AN - SCOPUS:79960756806
VL - 37
SP - 697
EP - 701
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 4
ER -
