Histological and histomorphometrical comparative study of the degradation and osteoconductive characteristics of α- and β-tricalcium phosphate in block grafts

Masahiro Yamada, Makoto Shiota, Yasuo Yamashita, Shohei Kasugai

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The purpose of the present study was to compare α- and β-tricalcium phosphate (TCP) as bone graft material for augmenting highly resorbed alveolar ridges. The cranial bones of 15 rabbits were used. Three titanium chambers filled with porous blocks of α-TCP, β-TCP, or blood clots were placed in each slit. The two TCP blocks had similar inner/outer structures and purities. Animals were sacrificed after 2, 4, and 8 weeks. Specimens were embedded in polyester resin as nondecalcified specimens, and evaluated both histologically and histomorphometrically. In both TCP groups, blocks had hardly degraded at 2 weeks while in the α-TCP group, the block had notably started degrading after 4 weeks. In the β-TCP group, degradation began at 4 weeks and this degradation had increased just slightly after 8 weeks. The α-TCP block degraded significantly more than the β-TCP block. Residual α-TCP particles surrounded by newly formed bone decreased over time, and both particles and newly formed bone were simultaneously absorbed by osteoclast-like cells. These observations suggest that residual α-TCP particles surrounded by newly formed bone may disappear progressively from bone and could be incorporated into the bone remodeling cycle in combination with newly formed bone.

Original languageEnglish
Pages (from-to)139-148
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume82
Issue number1
DOIs
Publication statusPublished - 2007 Jul 1
Externally publishedYes

Keywords

  • Animal model
  • Biodegradation
  • Bone remodeling
  • Calcium phosphate(s)
  • Osteogenesis

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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