Histologic localization of terminal complement complexes in renal diseases. An immunohistochemical study

T. Ootaka, M. Suzuki, K. Sudo, H. Sato, J. Seino, T. Saito, K. Yoshinaga

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Histologic localizations of terminal complement complexes (TCCs) were examined and compared with clinical findings in 154 patients with various renal diseases. Immunohistochemical demonstration of TCCs was carried out on ethanol-fixed paraffin-embedded renal biopsy specimens by indirect immunoperoxidase technique. In glomerular diseases that are thought to be immune-complex glomerulonephritis (IC-GN), such as IgA-nephropathy, membraneous nephropathy, and systemic lupus erythematosus (SLE), TCCs were demonstrated in a pattern similar to that of immunoglobulins and C3, indicating that TCCs were induced by immune complexes. The intensity of TCC deposition was correlated with the morphologic destruction of glomeruli or serum creatinine levels with IgA-nephropathy, with urine protein in membraneous nephropathy, and with serum C4 in SLE. TCC deposits without IC were also observed in tissue damages without disease specificity such as glomerular or vascular sclerosis and tubulointerstitial lesions. These findings suggested the existence of various roles of TCCs in renal injury, according to IC-mediated or non-IC-mediated mechanism acting in individual diseases.

Original languageEnglish
Pages (from-to)144-151
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume91
Issue number2
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Histologic localization of terminal complement complexes in renal diseases. An immunohistochemical study'. Together they form a unique fingerprint.

Cite this