TY - JOUR
T1 - Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis
AU - Rajasekaran, Narendiran
AU - Solomon, Samuel
AU - Watanabe, Takeshi
AU - Ohtsu, Hiroshi
AU - Gajda, Mieczyslaw
AU - Bräuer, Rolf
AU - Illges, Harald
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Serum transfer from arthritic K/BxN mice into naive animals results in arthritis. Mast cells have been shown to be essential since mice lacking these cell type do not develop arthritis upon serum injection. Mast cell function depends on the release of granules filled with mediators such as histamine. Mice deficient in histidine decarboxylase (HDC-/-) that do not produce histamine and mice deficient for histamine receptor 1 (H1R-/-) or histamine receptor 2 (H2R-/-) were injected with arthritogenic sera from the K/BxN mice, and the progression of arthritis was observed through the next 2 weeks. HDC-/- mice that are histamine free developed a milder form of arthritis in comparison with the wild-type controls. In both receptor-deficient mice as well as in wild-type controls, the onset and severity of clinical arthritis and ankle thickening occurred during day 1 to 3. These results indicate that histamine is required but not indispensable for the development of serum-induced arthritis and histamine receptors other than those studied here may be involved. The Japanese Society for Immunology.
AB - Serum transfer from arthritic K/BxN mice into naive animals results in arthritis. Mast cells have been shown to be essential since mice lacking these cell type do not develop arthritis upon serum injection. Mast cell function depends on the release of granules filled with mediators such as histamine. Mice deficient in histidine decarboxylase (HDC-/-) that do not produce histamine and mice deficient for histamine receptor 1 (H1R-/-) or histamine receptor 2 (H2R-/-) were injected with arthritogenic sera from the K/BxN mice, and the progression of arthritis was observed through the next 2 weeks. HDC-/- mice that are histamine free developed a milder form of arthritis in comparison with the wild-type controls. In both receptor-deficient mice as well as in wild-type controls, the onset and severity of clinical arthritis and ankle thickening occurred during day 1 to 3. These results indicate that histamine is required but not indispensable for the development of serum-induced arthritis and histamine receptors other than those studied here may be involved. The Japanese Society for Immunology.
KW - Histamine receptor
KW - Histidine decarboxylase
KW - K/BxN mouse model
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U2 - 10.1093/intimm/dxp092
DO - 10.1093/intimm/dxp092
M3 - Article
C2 - 19762454
AN - SCOPUS:71049186778
VL - 21
SP - 1263
EP - 1268
JO - International Immunology
JF - International Immunology
SN - 0953-8178
IS - 11
ER -