We investigated the relationship between histamine and muscarinic cholinergic neurons in central nervous system (CNS)—mediated glucose regulation in anesthetized fed rats. The injection of pyrilamine (5×10−7 mol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of histamine (5×10−7 mol). Ranitidine (5×10−7 mol), however, did not suppress this hyperglycemia. The injection of atropine (5×10−9−5×10−7 mol) into the third cerebral ventricle suppressed the histamine-induced hyperglycemia in a dose-dependent manner. These findings suggest that histamine induction of CNS-mediated hyperglycemia involves neuronal transmission not only via H1 receptors but also, at least in part, by muscarinic cholinergic neurons.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)