Histamine-induced, central nervous system-mediated hyperglycemia is suppressed by atropine in the brain

Katsunori Nonogaki, Li Xianzhu, Tatsuo Tamagawa, Genichi Watanabe, Yasuo Hiyoshi, Kuniaki Ozawa, Nobuo Sakamoto, Akihisa Iguchi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We investigated the relationship between histamine and muscarinic cholinergic neurons in central nervous system (CNS)—mediated glucose regulation in anesthetized fed rats. The injection of pyrilamine (5×10−7 mol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of histamine (5×10−7 mol). Ranitidine (5×10−7 mol), however, did not suppress this hyperglycemia. The injection of atropine (5×10−9−5×10−7 mol) into the third cerebral ventricle suppressed the histamine-induced hyperglycemia in a dose-dependent manner. These findings suggest that histamine induction of CNS-mediated hyperglycemia involves neuronal transmission not only via H1 receptors but also, at least in part, by muscarinic cholinergic neurons.

Original languageEnglish
Pages (from-to)PL-107-PL-110
JournalLife Sciences
Volume52
Issue number15
DOIs
Publication statusPublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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