Histamine H1 receptor binding capacities in the amygdalas of the amygdaloid kindled rat

H. Toyota, Chihiro Ito, Kazuhiko Yanai, M. Sato, T. Watanabe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The histamine H1 receptor binding capacity of the amygdalas of amygdaloid kindled rats was studied. In the kindled nonstimulated amygdala, significant decrease in K(D) and B(max) values compared with those of control amygdala were found 1 week after the last kindled seizure. One month after the last kindled seizure, the decreased K(D) value was sustained in the kindled nonstimulated amygdala. This decreased B(max) value 1 week after the last kindled seizure in nonstimulated amygdala seizure susceptibility. The decreased K(D) value in nonstimulated amygdala observed until 1 month after the last kindled seizure indicated the long-lasting increment of binding affinity of the pyrilamine binding site of the histamine H1 receptor in the steady state of kindled seizure susceptibility.

Original languageEnglish
Pages (from-to)2177-2180
Number of pages4
JournalJournal of Neurochemistry
Volume72
Issue number5
DOIs
Publication statusPublished - 1999 Jan 1

Keywords

  • Binding affinity
  • Histamine H receptor
  • Kindling
  • Receptor binding
  • Seizure susceptibility

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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