Histamine helps development of eczematous lesions in experimental contact dermatitis in mice

Masahiro Seike, Tomoya Takata, Mitsunori Ikeda, Hajime Kodama, Tadashi Terui, Hiroshi Ohtsu

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mice in which contact dermatitis was developed by repeated application of diphenylcyclopropenone. Development of eczematous lesions in contact dermatitis was suppressed in histamine-deficient mice compared to wild-type mice. H1 agonist ((6-12-(4-imidazol)ethylamino)-N-(4- trifluoro- methylphenyl)hepatanecarboxamide) promoted development of eczematous lesions in histamine-deficient mice. H1 receptor antagonist (loratadine) suppressed development of eczematous lesions in wild-type mice, whereas H2 agonist (dimaprit) and receptor antagonist (cimetidine) were ineffective. These results suggest that histamine facilitates the development of eczematous lesions in a murine model of contact dermatitis via H1 receptors.

Original languageEnglish
Pages (from-to)68-74
Number of pages7
JournalArchives of Dermatological Research
Volume297
Issue number2
DOIs
Publication statusPublished - 2005 Aug 1

Keywords

  • Contact dermatitis
  • H receptor
  • Histamine

ASJC Scopus subject areas

  • Dermatology

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