@article{9428a12b8aba4c61a01a26ed62bc23e5,
title = "Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents",
abstract = "The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro electrophysiology data, however, show a markedly different dorsoventral organization of the hippocampal projection to the medial EC (MEC). While dorsal hippocampal projections are confined to the dorsal MEC, ventral hippocampal projections innervate both dorsal and ventral MEC. Further, whereas the dorsal hippocampus preferentially targets layer Vb (LVb) neurons, the ventral hippocampus mainly targets cells in layer Va (LVa). This connectivity scheme differs from hippocampal projections to the lateral EC, which are topographically organized along the dorsoventral axis. As LVa neurons project to telencephalic structures, our findings indicate that the ventral hippocampus regulates LVa-mediated entorhinal-neocortical output from both dorsal and ventral MEC. Overall, the marked dorsoventral differences in hippocampal-entorhinal connectivity impose important constraints on signal flow in hippocampal-neocortical circuits.",
keywords = "CP: Neuroscience, anterograde tracing, dorsoventral axis, electrophysiology, hippocampal area CA1, hippocampal output circuit, lateral entorhinal cortex, layer V, medial entorhinal cortex, rodents, subiculum",
author = "Shinya Ohara and M{\"a}rt Rannap and Tsutsui, {Ken Ichiro} and Andreas Draguhn and Egorov, {Alexei V.} and Witter, {Menno P.}",
note = "Funding Information: This work was supported by the following grants and organizations. From the Japan Society for the Promotion of Science to S.O.: KAKENHI Grant Numbers JP21H00178 and JP19K06917 . From the Japan Science and Technology Agency to S.O.: PRESTO Grant Number JPMJPR21S3 . From the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) to A.V.E.: Grant number 430282670 (EG134/2-1) . Further support (to M.P.W.) was provided by The Kavli Foundation and the Norwegian Research Council: infrastructure grant NORBRAIN 197467 and the Centre of Excellence Scheme - Centre for Neural Computation 223262 . We thank the Nikon Imaging Center at Heidelberg University for access to the Nikon C2 laser scanning confocal microscope. Funding Information: This work was supported by the following grants and organizations. From the Japan Society for the Promotion of Science to S.O.: KAKENHI Grant Numbers JP21H00178 and JP19K06917. From the Japan Science and Technology Agency to S.O.: PRESTO Grant Number JPMJPR21S3. From the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) to A.V.E.: Grant number 430282670 (EG134/2-1). Further support (to M.P.W.) was provided by The Kavli Foundation and the Norwegian Research Council: infrastructure grant NORBRAIN 197467 and the Centre of Excellence Scheme - Centre for Neural Computation 223262. We thank the Nikon Imaging Center at Heidelberg University for access to the Nikon C2 laser scanning confocal microscope. S.O. collected and analyzed the anatomical data. M.R. carried out whole-cell recordings. M.R. and A.V.E. performed the electrophysiological and corresponding morphological data analysis. All authors conceptualized the study, interpreted the results, and wrote the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = jan,
day = "31",
doi = "10.1016/j.celrep.2023.112001",
language = "English",
volume = "42",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}