Hippocampal CA1 pyramidal cells of rats have four voltage-dependent calcium conductances

K. Takahashi, M. Wakamori, N. Akaike

Research output: Contribution to journalArticlepeer-review

104 Citations (Scopus)

Abstract

In isolated rat hippocampal neurons, we observed 4 voltage- and extracellular Ca2+-dependent conductances; i.e. the T-, N- and L-type Ca2+ currents and tetrodotoxin-sensitive transient Ca2+ current. Intracellular perfusion with F- suppressed irreversibly the L-type Ca2+ current and partially the N-type one. ω-Conotoxin inhibited selectively the L-type Ca2+ current. Amiloride reduced strongly the T-type Ca2+ current without affecting the L-type one. Gd3+, nicardipine, phenytoin and octanol had no specific inhibition on the T-, N- and L-type Ca2+ currents. Thereby, the pharmacological property of mammalian CNS neurons for Ca2+ channel blockers considerably differs from that in the peripheral and cultured cells.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalNeuroscience Letters
Volume104
Issue number1-2
DOIs
Publication statusPublished - 1989 Sep 25

Keywords

  • CA1 pyramidal cell
  • Calcium channel blocker
  • Calcium-sensitive current
  • Concentration-clamp
  • Intracellular perfusion
  • Rat hippocampal cell

ASJC Scopus subject areas

  • Neuroscience(all)

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