Methods for highly stereoselective generation of both Z- and E-enolates of a β-amino ester have been developed on the basis of a conjugate addition of lithium N-benzyltrimethylsilylamide to methyl crotonate and applied to stereoselective synthesis of anti,syn- and syn,anti-β-amino-β′- hydroxy esters by treatment with aldehyde.
|Number of pages||2|
|Journal||Journal of the Chemical Society, Chemical Communications|
|Publication status||Published - 1989 Jan 1|
ASJC Scopus subject areas
- Molecular Medicine