Highly stereocontrolled and concise asymmetric synthesis of the β-Lactam framework via a TCC method

Naoki Asao, Takashi Shimada, Naofumi Tsukada, Yoshinori Yamamoto

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    The conjugate addition of LSA 1 to t-butyl (4S)-4-(trityl)oxy-2-pentenoate 2d followed by aldol condensation with acetaldehyde produces a key intermediate 3 to β-lactam derivatives as a single diastereoisomer in 77 % yield.

    Original languageEnglish
    Pages (from-to)8425-8428
    Number of pages4
    JournalTetrahedron Letters
    Volume35
    Issue number45
    DOIs
    Publication statusPublished - 1994 Nov 7

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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