Highly sensitive detection of catecholamine with interdigitated array microelectrodes in HPLC

Masaya Takahashi, Masao Morita, Osamu Niwa, Hisao Tabei

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The highly sensitive detection of catecholamine has been achieved by using an interdigitated array (IDA) microelectrode as an electrochemical detector in a microbore high-performance liquid chromatography (HPLC) system. The current responses for catecholamine are measured for IDA electrodes with different gaps between their adjacent band electrodes. An IDA electrode with a narrow gap produces a high current density and reduces the influence of the auxiliary electrode position on the current response. The current response measured for an IDA electrode incorporated in the microbore HPLC system is about four times greater than that measured for a combination of the same IDA electrode and an ordinary sized column due to current enhancement by redox cycling in the slower stream.

Original languageEnglish
Pages (from-to)336-339
Number of pages4
JournalSensors and Actuators: B. Chemical
Volume13
Issue number1-3
DOIs
Publication statusPublished - 1993 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry
  • Electrical and Electronic Engineering

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