Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

Yusuke Sato, Yushuang Zhang, Takehiro Seino, Takashi Sugimoto, Seiichi Nishizawa, Norio Teramae

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

We report on highly selective binding of a naphthyridine derivative with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes; the binding-induced fluorescence quenching is applicable to the analysis of a C-related single-base mutation in DNAs amplified by PCR.

Original languageEnglish
Pages (from-to)4003-4006
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number20
DOIs
Publication statusPublished - 2012 May 28

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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