Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

Yusuke Sato; Yushuang Zhang; Takehiro Seino; Takashi Sugimoto; Seiichi Nishizawa; Norio Teramae

doi:10.1039/c2ob25513h

Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

Yusuke Sato, Yushuang Zhang, Takehiro Seino, Takashi Sugimoto, Seiichi Nishizawa, Norio Teramae

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We report on highly selective binding of a naphthyridine derivative with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes; the binding-induced fluorescence quenching is applicable to the analysis of a C-related single-base mutation in DNAs amplified by PCR.

Original language	English
Pages (from-to)	4003-4006
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	20
DOIs	https://doi.org/10.1039/c2ob25513h
Publication status	Published - 2012 May 28

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c2ob25513h

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Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes. / Sato, Yusuke; Zhang, Yushuang; Seino, Takehiro; Sugimoto, Takashi; Nishizawa, Seiichi; Teramae, Norio.

In: Organic and Biomolecular Chemistry, Vol. 10, No. 20, 28.05.2012, p. 4003-4006.

Research output: Contribution to journal › Article › peer-review

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AU - Sugimoto, Takashi

AU - Nishizawa, Seiichi

AU - Teramae, Norio

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Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

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