Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

Yusuke Sato; Yushuang Zhang; Takehiro Seino; Takashi Sugimoto; Seiichi Nishizawa; Norio Teramae

doi:10.1039/c2ob25513h

Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

Yusuke Sato, Yushuang Zhang, Takehiro Seino, Takashi Sugimoto, Seiichi Nishizawa, Norio Teramae

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We report on highly selective binding of a naphthyridine derivative with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes; the binding-induced fluorescence quenching is applicable to the analysis of a C-related single-base mutation in DNAs amplified by PCR.

Original language	English
Pages (from-to)	4003-4006
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	20
DOIs	https://doi.org/10.1039/c2ob25513h
Publication status	Published - 2012 May 28

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c2ob25513h

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abstract = "We report on highly selective binding of a naphthyridine derivative with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes; the binding-induced fluorescence quenching is applicable to the analysis of a C-related single-base mutation in DNAs amplified by PCR.",

author = "Yusuke Sato and Yushuang Zhang and Takehiro Seino and Takashi Sugimoto and Seiichi Nishizawa and Norio Teramae",

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AU - Sato, Yusuke

AU - Zhang, Yushuang

AU - Seino, Takehiro

AU - Sugimoto, Takashi

AU - Nishizawa, Seiichi

AU - Teramae, Norio

PY - 2012/5/28

Y1 - 2012/5/28

N2 - We report on highly selective binding of a naphthyridine derivative with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes; the binding-induced fluorescence quenching is applicable to the analysis of a C-related single-base mutation in DNAs amplified by PCR.

AB - We report on highly selective binding of a naphthyridine derivative with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes; the binding-induced fluorescence quenching is applicable to the analysis of a C-related single-base mutation in DNAs amplified by PCR.

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AN - SCOPUS:84860712901

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ER -

Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes

Abstract

ASJC Scopus subject areas

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