Highly regioselective palladium-catalyzed annulation reactions of heteroatom-substituted allenes for synthesis of condensed heterocycles

Kiyofumi Inamoto, Akio Yamamoto, Kazutoshi Ohsawa, Kou Hiroya, Takao Sakamoto

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

We have developed a highly regioselective synthesis of heterocycles via palladium-catalyzed annulation reaction of heteroatom-substituted allenes. Various aryl halides were reacted and one regioisomer was observed exclusively in all reactions. In addition, subsequent functionalizations of annulated products were carried out using alkyl metal reagents, and the introduction of alkyl moieties was accomplished.

Original languageEnglish
Pages (from-to)1502-1507
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number11
DOIs
Publication statusPublished - 2005 Nov

Keywords

  • Alkyl metal reagent
  • Allene
  • Annulation
  • Heterocycle
  • Palladium

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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